Abstract #1876

Signal behavior of Ultra-High-b radial DWI (UHb-rDWI) signal in different tract of the cervical spinal cord

Bijaya Thapa^1,2, Nabraj Sapkota^1,2, YouJung Lee¹, EunJu Kim¹, John Rose³, Lubdha M. Shah⁴, and Eun-Kee Jeong^1,4

¹Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, ²Department of Physics and Astronomy, University of Utah, Salt Lake City, UT, United States, ³Department of Neurology, University of Utah, Salt Lake City, UT, United States, ⁴Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

The ultrahigh-b radial DWI (UHb-rDWI) technique is used to study the white matter disease in the spinal cord. The diffusion signal from the extra axonal (EA) space drops to noise level while that from the intra axonal (IA) space is almost constant at UHb region for the myelinated axons where the myelin layers prohibit the exchange of water molecules between IA and EA spaces. However for partially or unmyelinated axons, the diffusion signal from IA space is no longer constant. The signal behavior at UHb region could be used as a biomarker for the demyelination and axonal loss.

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