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Abstract #1877

Reliability of Single- and Multi-TI ASL measurements with a clinical product sequence

Antonio Ricciardi1,2, Marco Castellaro3, Alberto Miglioranza3, Giancarlo Germani4,5, Paolo Vitali4,5, Giuseppe Micieli6, Egidio D'Angelo7,8, Fulvia Palesi7,9, Gloria Castellazzi7,10, Claudia AM Gandini Wheeler-Kingshott1,7,8, Enrico De Vita11,12, and Alessandra Bertoldo3

1Institute of Neurology, University College London, London, United Kingdom, 2Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3Department of Information Engineering, University of Padova, Padova, Italy, 4Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy, 5Neuroradiology Unit, C. Mondino National Neurological Institute, Pavia, Italy, 6Department of Emergency Neurology, C. Mondino National Neurological Institute, Pavia, Italy, 7Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, 8Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 9Department of Physics, University of Pavia, Pavia, Italy, 10Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, 11Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, 12Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCL Hospitals Foundation Trust, University College London, London, United Kingdom

Single-TI Arterial Spin Labeling (ASL) is sensitive to delayed arterial arrival time (AAT) of blood in the tissues. Multi-TI was introduced to overcome this limitation. Moreover, it allows estimating AAT that, therefore, can shed some light in the characterization of the brain haemodynamic processes. In this study, we compare the reliability of the multi-TI approach to the single-TI in a test-retest protocol. The sequence tested was the Siemens product sequence FAIR PASL with 3D-GRASE readout. Results show an overall good level of reliability both in single- and multi-TI, but also a possible sensitivity to the macro-vascular component in multi-TI data.

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