Abstract #1882

Investigating the Sensitivity to Partial Volume Estimates of Partial Volume Correction for Single Postlabeling Delay Pseudo-continuous ASL

Moss Y Zhao¹, Egill Rostrup^2,3, Otto M Henriksen³, Yingyi Xiao⁴, and Michael A Chappell¹

¹Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ²Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Glostrup, Copenhagen, Denmark, ³Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Blegdamsvej, Copenhagen, Denmark, ⁴St Hilda's College, University of Oxford, Oxford, United Kingdom

This work investigates the sensitivity of partial volume correction methods to partial volume estimates using single-PLD PCASL. Random and biased errors were applied to partial volume estimates to simulate the variabilities in tissue segmentation. The results have indicated that current partial volume correction methods trade off accuracy in spatial variations in CBF against sensitivity to noise and errors in the partial volume estimates.

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