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Abstract #1882

Investigating the Sensitivity to Partial Volume Estimates of Partial Volume Correction for Single Postlabeling Delay Pseudo-continuous ASL

Moss Y Zhao1, Egill Rostrup2,3, Otto M Henriksen3, Yingyi Xiao4, and Michael A Chappell1

1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Glostrup, Copenhagen, Denmark, 3Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet Blegdamsvej, Copenhagen, Denmark, 4St Hilda's College, University of Oxford, Oxford, United Kingdom

This work investigates the sensitivity of partial volume correction methods to partial volume estimates using single-PLD PCASL. Random and biased errors were applied to partial volume estimates to simulate the variabilities in tissue segmentation. The results have indicated that current partial volume correction methods trade off accuracy in spatial variations in CBF against sensitivity to noise and errors in the partial volume estimates.

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