Abstract #1881

Estimation of Cerebral Blood Flow and Arterial Transit Time Using Partial Volume Corrected Multi-TI Arterial Spin Labeling Imaging

Youngkyoo Jung^1,2,3, Megan E Johnston², and Christopher T Whitlow^1,2,3

¹Radiology, Wake Forest School of Medicine, Winston-Salem, NC, United States, ²Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, United States, ³Clinical and Translational Sciences Institute, Wake Forest School of Medicine, Winston-Salem, NC, United States

A novel PVC algorithm using Multi-TI ASL, acquiring ASL images at multiple PLDs, has been proposed to estimate CBF and ATT in GM and WM separately. A 3D kernel was used to reduce noise sensitivity and improve the estimation power. The proposed method successfully estimated four perfusion parameters (GM CBF, GM ATT, WM CBF, and WM ATT) simultaneously, and may allow region- or voxel-based perfusion analyses in WM, as well as GM.

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