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Abstract #1880

Cerebral Blood Flow and Bolus Arriving Time Changes in Patients with Diabetes Detected by Multi-TI ASL

Yelong Shen1, Bin Zhao1, Lirong Yan2, Kay Jann2, Guangbin Wang1, Junli Wang1, Bao Wang1, Josef Pfeuffer3, Tianyi Qian4, and Danny JJ Wang2

1Shandong Medical Imaging Research Institute, School of Medicine, Shandong University, Jinan, People's Republic of China, 2Laboratory of FMRI Technology (LOFT),Mark & Mary Stevens Neuroimaging and Informatics Institute,Keck School of Medicine,University of Southern California (USC), LA, CA, United States, 3Siemens Healthcare, Erlangen, Germany, 4Siemens Healthcare, MR Collaborations NE Asia, Beijing, People's Republic of China

This study aimed to simultaneously measure cerebral blood flow (CBF) and bolus arriving time (BAT) in a cohort of subjects with type II diabetes, and compared the results with those of matched control subjects using a multi-TI 3D GRASE pulsed-ASL (PASL) sequence. The voxel-based analysis showed that the CBF and BAT values in patients with diabetes presented significant differences compared to healthy subjects, especially in some particular areas of the brain. These differences may be related to functional changes in patients with diabetes, which may have occurred before the onset of the symptoms.

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