It has been hypothesized that in multi-delay arterial spin labeling (ASL), employing T1-adjusted labeling durations (LDs) should provide a more balanced signal-to-noise (SNR) across ASL signals, therefore improving the accuracy of the transit delay (TD) and perfusion estimation. However, this claim has not been thoroughly tested. In this study, we evaluated the effects on the TD and perfusion estimation using LDs both with and without T1-adjusted weighting, using the Hadamard-encoded multi-delay ASL sequence. Using Monte Carlo simulations and in vivo experiments, T1-adjusted weighting was more prone to noise and was likely to underestimate the TD and perfusion measurements compared to that without.
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