Abstract #1884

White matter cerebral blood flow in a large healthy cohort from the CARDIA study

Sudipto Dolui^1,2, Guray Erus¹, David R. Jacobs, Jr.³, R. Nick Bryan¹, and John A. Detre^1,2

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, ³Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States

By analyzing cerebral blood flow (CBF) maps generated from arterial spin labeling (ASL) data averaged across 436 cognitively healthy middle-aged subjects from the CARDIA study, we characterized the CBF distribution in white matter. CBF is specifically decreased in periventricular regions in a pattern not reflective of partial volume effects as estimated from the structural MRI segmentation. White matter lesion frequency mapping based on Fluid Attenuated Inversion Recovery (FLAIR) images from the same cohort demonstrates that lesions tend to occur in regions where group averaged CBF is lowest.

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