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Abstract #1899

Optimization of Echo Times for CBV Measurements in the Arterial Input Function, Brain, and High-Grade Tumor Tissue using Error Analysis for DSC-MRI

Laura C. Bell1, Mark D. Does2, Ashley M. Stokes1, Leslie C. Baxter1, Kathleen M. Schmainda3, and C. Chad Quarles1

1Barrow Neurological Institute, Phoenix, AZ, United States, 2Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 3Medical College of Wisconsin, Milwaukee, WI, United States

This abstract demonstrates that the optimal TE for a single-echo DSC-MRI acquisition is 30-35 ms (without a preload) and 23-30 ms (with a standard full-dose preload) for a high-grade glioma population. Optimal TEs were calculated using error analysis on T2* values quantified during the first-pass of contrast agent using dual-echo DSC, and were shown to be the weighted-average of these values. Furthermore, we demonstrate that the optimal TE depends on tissue type (tumor/healthy tissue/AIF) and preload.

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