Abstract #1899

Optimization of Echo Times for CBV Measurements in the Arterial Input Function, Brain, and High-Grade Tumor Tissue using Error Analysis for DSC-MRI

Laura C. Bell¹, Mark D. Does², Ashley M. Stokes¹, Leslie C. Baxter¹, Kathleen M. Schmainda³, and C. Chad Quarles¹

¹Barrow Neurological Institute, Phoenix, AZ, United States, ²Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ³Medical College of Wisconsin, Milwaukee, WI, United States

This abstract demonstrates that the optimal TE for a single-echo DSC-MRI acquisition is 30-35 ms (without a preload) and 23-30 ms (with a standard full-dose preload) for a high-grade glioma population. Optimal TEs were calculated using error analysis on T2* values quantified during the first-pass of contrast agent using dual-echo DSC, and were shown to be the weighted-average of these values. Furthermore, we demonstrate that the optimal TE depends on tissue type (tumor/healthy tissue/AIF) and preload.

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