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Abstract #1900

Improving Simultaneous T1 and T2* Measurements for Dynamic Susceptibility Contrast MRI using a 3D Distributed Spirals Sequence

Laura C. Bell1, Dallas C. Turley2, Natenael B. Semmineh1, James G. Pipe2, and C. Chad Quarles1

1Translational Bioimaging Group, Barrow Neurological Institute, Phoenix, AZ, United States, 2MR Technology Design Group, Barrow Neurological Institute, Phoenix, AZ, United States

Multi-echo (ME) DSC-MRI enables the simultaneous assessment of contrast-agent induced T1 and T2* changes, but its sensitivity to and the quantification of these T1 changes could be confounded by long TR and TE. Using simulations, we demonstrate that conventional 2D ME scans underestimate contrast agent concentration and DCE-MRI kinetic parameters. To solve this problem, we propose a 3D ME spiral acquisition that enables lower TRs and minimal TEs for improved T1 quantification and a range of echo times to main T2* sensitivity.

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