Abstract #1900

Improving Simultaneous T1 and T2* Measurements for Dynamic Susceptibility Contrast MRI using a 3D Distributed Spirals Sequence

Laura C. Bell¹, Dallas C. Turley², Natenael B. Semmineh¹, James G. Pipe², and C. Chad Quarles¹

¹Translational Bioimaging Group, Barrow Neurological Institute, Phoenix, AZ, United States, ²MR Technology Design Group, Barrow Neurological Institute, Phoenix, AZ, United States

Multi-echo (ME) DSC-MRI enables the simultaneous assessment of contrast-agent induced T₁ and T₂* changes, but its sensitivity to and the quantification of these T₁ changes could be confounded by long TR and TE. Using simulations, we demonstrate that conventional 2D ME scans underestimate contrast agent concentration and DCE-MRI kinetic parameters. To solve this problem, we propose a 3D ME spiral acquisition that enables lower TRs and minimal TEs for improved T₁ quantification and a range of echo times to main T₂* sensitivity.

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