Signal loss resulting from $$$R_2^*$$$ effects is usually neglected in fast dynamic contrast-enhanced perfusion imaging. A new flow-compensated 3D RF-spoiled dual gradient echo sequence was designed to quantify the $$$R_2^*$$$ variation during a bolus injection of contrast agent and its effect on cerebral blood flow measurement. Moderate $$$R_2^*$$$ effects are found to be amplified by the non-linear relationship between signal ratio and concentration. This is shown to lead to substantial changes in peak arterial input function and measured cerebral blood flow.
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