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Abstract #1902

Correction of R2* Effects in Arterial Input Function of Fast Dynamic Contrast-Enhanced MRI for Accurate Cerebral Blood Flow Measurement

Benoit Bourassa-Moreau1, Réjean Lebel1, Guillaume Gilbert2, and Martin Lepage1

1Département de médecine nucléaire et radiobiologie, Centre d'imagerie moléculaire de Sherbrooke, Sherbrooke, QC, Canada, 2MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada

Signal loss resulting from $$$R_2^*$$$ effects is usually neglected in fast dynamic contrast-enhanced perfusion imaging. A new flow-compensated 3D RF-spoiled dual gradient echo sequence was designed to quantify the $$$R_2^*$$$ variation during a bolus injection of contrast agent and its effect on cerebral blood flow measurement. Moderate $$$R_2^*$$$ effects are found to be amplified by the non-linear relationship between signal ratio and concentration. This is shown to lead to substantial changes in peak arterial input function and measured cerebral blood flow.

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