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Abstract #1903

Improved Arterial Input Function Measurements Using Phase-versus-Time and Modified Look-Locker Inversion Recovery: Phantom Validation Study

Nicholas Majtenyi1, Gregory O. Cron2,3,4, Hanif Gabrani-Juma5, Andreas Greiser6, Robert A. deKemp7, Ran Klein5, Thanh B. Nguyen8, and Ian G. Cameron1,2,4

1Carleton University, Ottawa, ON, Canada, 2Medical Imaging, The Ottawa Hospital, 3The Ottawa Hospital Research Institute, 4Radiology, The University of Ottawa, 5Division of Nuclear Medicine, The Ottawa Hospital, 6Siemens Healthcare, Erlangen, Germany, 7Cardiac PET Centre, University of Ottawa Heart Institute, 8Radiology, The Ottawa Hospital

Dynamic contrast-enhanced (DCE)-MRI is used to quantify organ perfusion abnormalities in many diseases, but is prone to errors. This study investigated the accuracy of a new method for measuring the arterial input function (AIF) in a flowing-water phantom using phase-versus-time measurements with pre- and post-DCE Modified Look-Locker Inversion Recovery (MOLLI) T1 measurements (Phase+MOLLI). The Phase+MOLLI technique provides an important improvement over previous methods since it avoids signal saturation and gives correct [Gd] values for the washout of the AIF. The Phase+MOLLI method was validated to be accurate, reproducible, and flow-insensitive so that it may be used for clinical DCE-MRI.

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