Abstract #1903

Improved Arterial Input Function Measurements Using Phase-versus-Time and Modified Look-Locker Inversion Recovery: Phantom Validation Study

Nicholas Majtenyi¹, Gregory O. Cron^2,3,4, Hanif Gabrani-Juma⁵, Andreas Greiser⁶, Robert A. deKemp⁷, Ran Klein⁵, Thanh B. Nguyen⁸, and Ian G. Cameron^1,2,4

¹Carleton University, Ottawa, ON, Canada, ²Medical Imaging, The Ottawa Hospital, ³The Ottawa Hospital Research Institute, ⁴Radiology, The University of Ottawa, ⁵Division of Nuclear Medicine, The Ottawa Hospital, ⁶Siemens Healthcare, Erlangen, Germany, ⁷Cardiac PET Centre, University of Ottawa Heart Institute, ⁸Radiology, The Ottawa Hospital

Dynamic contrast-enhanced (DCE)-MRI is used to quantify organ perfusion abnormalities in many diseases, but is prone to errors. This study investigated the accuracy of a new method for measuring the arterial input function (AIF) in a flowing-water phantom using phase-versus-time measurements with pre- and post-DCE Modified Look-Locker Inversion Recovery (MOLLI) T₁ measurements (Phase+MOLLI). The Phase+MOLLI technique provides an important improvement over previous methods since it avoids signal saturation and gives correct [Gd] values for the washout of the AIF. The Phase+MOLLI method was validated to be accurate, reproducible, and flow-insensitive so that it may be used for clinical DCE-MRI.

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