Abstract #1904

Dynamic Susceptibility Contrast MRI at 7T: Tail Scaling Analysis and Inferences About Field Strength Dependence

Linda Knutsson^1,2, Xiang Xu^3,4, Freddy Ståhlberg^1,5, Peter B. Barker³, Pia Sundgren⁵, Peter C.M. van Zijl^3,4, and Ronnie Wirestam¹

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Department of Radiology (Adjunct), Johns Hopkins School of Medicine, Baltimore, MD, United States, ³Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵Department of Diagnostic Radiology, Lund University, Lund, Sweden

In this study, a dynamic susceptibility contrast MRI (DSC-MRI) protocol for cerebral perfusion imaging at 7T was designed. With reduced contrast agent dose, the obtained perfusion maps showed the same visual appearance as seen at lower field strengths. In addition, a correction method was applied to obtain quantitative estimates of CBF and CBV in order to assess whether previous predictions of a field-strength dependence of the in vivo transverse relaxivity, leading to overestimated perfusion estimates, were supported. We concluded that assumptions of a field-strength dependence were plausible, based on observations of further elevated CBF and CBV estimates at 7T.

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