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Abstract #1905

Impact of Reference Time Curve Determination on the Correction of Contrast Agent Extravasation in Dynamic Susceptibility Contrast MRI

Mu-Lan Jen1, Ping Hou1, Jason M Johnson2, Donald F Schomer2, and Ho-Ling Liu1

1Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States, 2Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States

This study investigated the influence of reference time curve determination on DSC leakage correction. Our findings suggested that the reference time curve obtained with inclusion of leaky tissue could lead a significantly different in K2, which supported that the probable error in lesion blood volume quantification with inaccurate automated segmentation process.

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