Abstract #1910

Influence of parameter initial values on DCE parameter estimates in pharmacokinetic modeling: a simulation study

Charlotte Debus^1,2,3,4, Ralf Floca⁵, Amir Abdollahi^1,2,3,4, and Michael Ingrisch⁶

¹German Cancer Consortium (DKTK), Heidelberg, Germany, ²Translational Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg, Germany, ⁴National Center for Tumor Diseases (NCT), Heidelberg, Germany, ⁵Software development for Integrated Diagnostics and Therapy, German Cancer Research Center DKFZ, ⁶Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich

In pharmacokinetic analysis of DCE-MRI data, the choice of initial parameter values for fitting has been reported to have a significant impact on the outcome of the optimization and hence, on parameter estimates. In this study, we investigated the influence of initial values by fitting simulated concentration time curves with varying combinations of initial parameters, using the two compartment exchange model. The resulting parameter estimates were visualized and compared to the true values, used for simulation, by means of relative errors. Results showed that the choice of initial values has little influence on the precision of the pharmacokinetic analysis.

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