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Abstract #1912

Measurement of Murine Single-Kidney Glomerular Filtration Rate using Dynamic Contrast Enhanced MRI

Kai Jiang1, Hui Tang1, Prassana K. Mishra2, Slobodan I. Macura2, and Lilach O. Lerman1

1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, 2Division of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States

A method for noninvasive assessment of mouse glomerular filtration rate (GFR) using dynamic contrast enhanced MRI (DCE-MRI) was developed and validated. The kinetics of gadolinium in the abdominal aorta and two kidneys were measured using a snapshot fast low angle shot based T1 mapping method with a temporal resolution of 1 s. A modified bi-compartmental model was used for quantification of GFR by a least-squares fitting. As a reference standard, GFR was also measured using FITC-inulin clearance. Single-kidney GFR measured from both methods showed a good agreement, suggesting the proposed DCE-MRI method provides an accurate measurement of murine single-kidney GFR.

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