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Abstract #1913

Patlak analysis of dynamic gadoxetic acid-enhanced MR imaging is an effective and  simpler alternative to compartmental pharmacokinetic modelling for assessing liver function

Matthew R Orton1, Mihaela Rata1, Dow-Mu Koh1,2, Maria Bali1,2, Robert Grimm3, David J Collins1, James A d'Arcy1, and Martin O Leach1

1CRUK Cancer Imaging Centre, Division of Radiotherapy and Imaging, Institute of Cancer Research, Sutton, United Kingdom, 2Departent of Radiology, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, 3Siemens Healthcare, Erlangen, Germany

Liver perfusion and function can be assessed using gadoxetic acid combined with DCE-MRI imaging and pharmacokinetic (PK) modelling. Whilst compartmental PK models give a good account of the contrast changes over the first five minutes of enhancement, the Patlak graphical approach is a simpler alternative that is more easily implemented. Patlak evaluation requires the specification of a delay time after which the initial transients in the uptake curves have decayed, so the purpose of this abstract is to present a preliminary evaluation of the sensitivity of liver uptake rate estimates to the Patlak delay time.

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