Liver perfusion and function can be assessed using gadoxetic acid combined with DCE-MRI imaging and pharmacokinetic (PK) modelling. Whilst compartmental PK models give a good account of the contrast changes over the first five minutes of enhancement, the Patlak graphical approach is a simpler alternative that is more easily implemented. Patlak evaluation requires the specification of a delay time after which the initial transients in the uptake curves have decayed, so the purpose of this abstract is to present a preliminary evaluation of the sensitivity of liver uptake rate estimates to the Patlak delay time.
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