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Abstract #1919

Whole Brain Dynamic Contrast-Enhanced MRI Study of Blood-Brain Barrier Disruption in Systemic Lupus Erythematosus Patients: Implications on the Choice of Tracer Kinetic Model

Dennis Lai-Hong Cheong1, Mary C Stephenson1, and Sen Hee Tay2

1Clinical Imaging Research Centre, Singapore, Singapore, 2Division of Rheumatology, National University Hospital, Singapore

Current evidence suggests that blood-brain barrier (BBB) integrity is one of the potential biomarkers to diagnose neuropsychiatric systemic lupus erythematosus patients. We use DCE MRI and performed tracer kinetic analysis using both a distributed parameter (DP) model and the modified Tofts (MT) model. More Leaky BBB in SLE patients with anti-NR2 in their sera than the controls was detected by the permeability related parameters from both models. However, Ktrans of MT model, which is commonly used in DCE MRI of cancer studies, might be less reliable than DP model permeability parameters in this study.

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