Dynamic-contrast-enhanced MRI (DCE-MRI) has been widely used to characterize microvasculature permeability. Recently, it was shown to reveal metabolic activity using the shutter-speed pharmacokinetic paradigm (SSP), in which steady-state intra/extracellular water exchange kinetics was incorporated into DCE-MRI data analysis. Interesting insights into DCE-MRI signals come from modeling the extravascular tissue MR signal. The questions addressed here are, “When can extravascular 1H2O longitudinal magnetization recovery from inversion/saturation still be described by a single-exponential process, and when can the intra/extracellular water exchange kinetics be accurately determined?”
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