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Abstract #1921

Assessment of hydrodynamics and T2 alterations in spontaneously hypertensive rat under short-term hyperhydration

Kun-I Chao1, Cheng-He Li1, Sheng-Min Huang1, Pei-Lun Yu1, Kung-Chu Ho2, Shang-Yueh Tsai3, Ping-Huei Tsai4, and Fu-Nien Wang1

1Biomedical Engineering and Environmental Science, National Tsing Hua Unerversity, Hsinchu, Taiwan, 2Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 3Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan, 4Department of Radiology, Taipei Medical University Hospital, Taipei, Taiwan

With a fluid infusion of 2% of body weight in the D2O perfusion imaging experiment, the tissues are expected in a hyperhydration state. In this study, we conduct both D2O and H2O infusion experiments on spontaneously hypertension rat (SHR). Fast and slow flow of brain were analyzed by a two-compartmental parallel model. Pre- and post-infusion T2 maps were acquired. The slow flow matched the T2 prolonged regions, which could be due to the CSF production and flow.

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