Abstract #1921

Assessment of hydrodynamics and T2 alterations in spontaneously hypertensive rat under short-term hyperhydration

Kun-I Chao¹, Cheng-He Li¹, Sheng-Min Huang¹, Pei-Lun Yu¹, Kung-Chu Ho², Shang-Yueh Tsai³, Ping-Huei Tsai⁴, and Fu-Nien Wang¹

¹Biomedical Engineering and Environmental Science, National Tsing Hua Unerversity, Hsinchu, Taiwan, ²Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ³Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan, ⁴Department of Radiology, Taipei Medical University Hospital, Taipei, Taiwan

With a fluid infusion of 2% of body weight in the D₂O perfusion imaging experiment, the tissues are expected in a hyperhydration state. In this study, we conduct both D₂O and H₂O infusion experiments on spontaneously hypertension rat (SHR). Fast and slow flow of brain were analyzed by a two-compartmental parallel model. Pre- and post-infusion T2 maps were acquired. The slow flow matched the T2 prolonged regions, which could be due to the CSF production and flow.

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