With a fluid infusion of 2% of body weight in the D2O perfusion imaging experiment, the tissues are expected in a hyperhydration state. In this study, we conduct both D2O and H2O infusion experiments on spontaneously hypertension rat (SHR). Fast and slow flow of brain were analyzed by a two-compartmental parallel model. Pre- and post-infusion T2 maps were acquired. The slow flow matched the T2 prolonged regions, which could be due to the CSF production and flow.