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Abstract #1922

Feasibility study of a Dialyzer as a multi-compartment Perfusion Phantom for microvascular tracer kinetic Modelling

Tanja Gaa1, Lothar R. Schad1, and Frank G. Zöllner1

1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Dynamic contrast enhanced MRI combined with tracer kinetic modelling allows for the determination of quantitative perfusion parameters. To achieve standardized examinations and data analysis, phantoms are employed to investigate the reproducibility of perfusion parameters by imitating tissue on capillary level. In this study we used a dialysis filter with a semipermeable membrane of the fibers which enables the simulation of two compartment kinetics and can thus serve as imitation of capillaries and interstitium which might be closer to the anatomical conditions.

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