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Abstract #1926

MR Contrast Effects of Intrinsically Gd-chelated Melanin Nanoparticles at 1.5 and 11.7 Tesla

Soojeong Cho1, Weiguo Li1, Andrew C Larson1, and Dong-Hyun Kim1

1Radiology, Northwestern University, Chicago, IL, United States

The development of polymeric contrast agents exhibiting a high MR relaxivity has been achieved using bio-inspired metal chelating melanin nanoparticle (Mel NP) synthesized with dopamine or L-3,4-dihydroxyphenylalanine (L-DOPA). In here, we described our simple one-pot synthesis to prepare new Gd chelated Mel NP and their specific features of efficient MR T1 imaging along with their high intrinsic Gd chelation efficiency.

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