The development of polymeric contrast agents exhibiting a high MR relaxivity has been achieved using bio-inspired metal chelating melanin nanoparticle (Mel NP) synthesized with dopamine or L-3,4-dihydroxyphenylalanine (L-DOPA). In here, we described our simple one-pot synthesis to prepare new Gd chelated Mel NP and their specific features of efficient MR T1 imaging along with their high intrinsic Gd chelation efficiency.
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