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Abstract #1927

Effect of vendor specific formalin composition and concentration on post-mortem MRI of human brain tissue

Christoph Birkl1, Martin Soellradl1, Anna Maria Toeglhofer2, Johannes Haybaeck2,3, Lukas Pirpamer1, Franz Fazekas1, Stefan Ropele1, and Christian Langkammer1

1Department of Neurology, Medical University of Graz, Graz, Austria, 2Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria, 3Department of Pathology, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany

Formalin fixation is common procedure to prevent tissue autolysis by crosslinking proteins. Not unexpectedly this affects the relaxation properties of the tissue. In addition, quantitative relaxation time constants of formalin fixed brain tissue show a broad variation across different studies. To investigate the contribution of the formulation of formalin to this variability we investigated MR relaxation times of pure formalin solutions from different vendors and the effect of formalin concentration on MR relaxation times of fixed brain tissue. Our results showed a strong variation of relaxation times depending on the concentration used and more importantly on the vendor specific composition of the formalin solutions.

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