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Abstract #1929

Characterization of the Four Pool Model in formalin-fixed sheep's brain using NMR spectroscopy

Alan P. Manning1, Alex L. MacKay1,2, and Carl A. Michal1

1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada

Despite its importance, T1 relaxation in brain and spinal cord is not well understood. The Four Pool Model gives a fundamental framework for its understanding in white and grey matter tissue. In this work, we characterize the Four Pool Model for the first time in formalin-fixed sheep's brain using NMR spectroscopy. We find this is a suitable system, and our results are consistent with previous studies: T1 is multi-exponential and the values measured result from a convolution of pure relaxation and exchange processes.

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