Abstract #1940

Determination of Oxygenation Extraction Fraction for People with Sickle Cell Anemia using Calibration Model Specific to SCA Blood

Wenbo Li^1,2, Xiang Xu^1,2, Peiying Liu¹, John Strouse^3,4, Hanzhang Lu¹, Peter van Zijl^1,2, and Qin Qin^1,2

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Division of Hematology, Duke University, Durham, NC, United States

For the blood T₂-based MRI oximetry methods, the calibration model to convert blood T₂ to blood oxygenation (Y) is critical to calculate the brain oxygen extraction fraction (OEF). Here, we established a calibration model specific to people with sickle cell anemia (SCA) using in vitro blood T₂ measurements on SCA blood samples under various conditions. The results show that the use of calibration models based on normal blood underestimate Y, and thus overestimate OEF, for individuals with SCA. Using a fast T₂ protocol to measure oxygenation in the internal jugular vein (IJV), the whole-brain OEF values of individuals with SCA were determined and compared with healthy volunteers.

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