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Abstract #1944

On the feasibility of synthetic sodium MRI based on tissue conductivity

Nazim Lechea1, Yu Peng Liao2, and N. Jon Shah1,2

1INM4, JARA-Faculty of Medicine, RWTH Aachen University, Aachen, Germany, Juelich, Germany, 2Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich, Juelich, Germany

The recently proposed magnetic resonance electrical property tomography opens new opportunities for sodium ion characterisation. In this study, a model was built by measuring electrical conductivity and sodium MRI in different saline solutions. We exploit this interdependence with additional temperature correction to build a synthetic sodium brain map based on in vivo electrical conductivity. The results were compared to sodium MRI measurements. A statistically significant Pearson correlation (p<0.001; r=0.43) was observed between the two modalities while Bland-Altman analysis revealed discrepancies between them with a mean difference ~4mMol/L in whole brain. The proposed approach facilitates tissue sodium extraction.

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