Meeting Banner
Abstract #1943

Combination of MT and R2* measurements to distinguish between contributions of semisolids and iron to R1

Xu Jiang1, Erika Raven1,2, Peter van Gelderen1, and Jeff H. Duyn1

1Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States, 2Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, DC, United States

In human brain, the apparent longitudinal relaxation rate (R1) primarily originates from magnetization transfer (MT) effects associated with the macromolecular 1H-proton fraction (f), although in some regions the iron concentration may contribute as well (Rooney, 2007). To quantify their relative contributions at 7 T, we measured f and R1 of water protons (R1,WP) corrected for MT effects using a pulsed, transient MT approach (van Gelderen, 2016). The iron concentration was taken from literature and correlated with R2*. The results indicate that the combination of R2* and MT measurements may provide a sensitive means to quantify R1,WP, f and iron concentration.

This abstract and the presentation materials are available to members only; a login is required.

Join Here