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Abstract #1958

Incorporating macroscale susceptibility in QSM reconstruction with 3D spiral acquisition.

Giang-Chau Ngo1,2, Berkin Bilgic3,4, Borjan Gagoski4,5, and Bradley P. Sutton1,2

1Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Boston Children’s Hospital, Boston, MA, United States

Macroscale magnetic susceptibility creates large variations in the phase images preventing the direct analysis of local tissue-dependent phase in quantitative susceptibility mapping. Unwrapping and background field removal are important steps for calculating tissue phases and susceptibility maps. In this work, a 3D spiral acquisition is combined with an image reconstruction pipeline modelling the macroscale magnetic susceptibility to provide more accurate tissue phases and susceptibility maps, by reducing image distortions and facilitating unwrapping and background phase removal.

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