Meeting Banner
Abstract #1971

Fast, Reliable 3D Amide Proton Transfer Imaging of Brain Tumors at 3T with Variably-accelerated Sensitivity Encoding (vSENSE)

Yi Zhang1, Hye-Young Heo1, Shanshan Jiang1, Paul A. Bottomley1, and Jinyuan Zhou1,2

1Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

The clinical use of amide proton transfer (APT) imaging is hindered by long scan times. Accuracy generally limits the use of conventional sensitivity encoding (SENSE) methods in APT, to an acceleration factor of 2. A novel variably-accelerated sensitivity encoding (vSENSE) method can provide more accurate results and therefore substantially higher overall acceleration factors than conventional SENSE. Here, vSENSE is further developed to eliminate the requirement that one fully-sampled APT frame be acquired, and extended to three dimensions (3D). Furthermore, we combine vSENSE with parallel transmit saturation, and apply it proactively to three normal volunteers and eleven patients with brain tumors.

This abstract and the presentation materials are available to members only; a login is required.

Join Here