Quantitative CEST MRI studies have so far been hindered by the fact that variations in multiple factors produce identical CEST effect changes. This remains the case when CEST MRI data are analysed using metrics that control for the contaminating effects of T1 and T2, such as APTR*. In this work we introduce isoAPTR*, a novel methodology which, in combination with independent measurement of labile proton concentration, can estimate the change in intracellular pH between two APTR* measurements. We demonstrate the utility of this method by applying it to measure the intracellular pH of U87 glioma in rats.
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