Abstract #1973

The comparison of different strategies for transmit field inhomogeneity correction of Amide-CEST and NOE effects at 7T

Vitaliy Khlebnikov¹, Johannes Windschuh², Jeroen CW Siero^1,3, Moritz Zaiss⁴, Peter R Luijten¹, Dennis WJ Klomp¹, and Hans Hoogduin¹

¹Department of Radology, University Medical Center Utrecht, Utrecht, Netherlands, ²Division of Medical Physics in Radiology, Deutsches Krebsforschungszentrum (DKFZ) [German Cancer Research Center], Heidelberg, Germany, ³Spinoza Center for Neuroimaging, Amsterdam, Netherlands, ⁴Scheffler, Max Planck Institute for Biological Cybernetics, Tübingen, Germany

We compared three methods for B1 correction of relaxation-compensated Amide-CEST and Nuclear Overhauser Enhancement (NOE) effects at 7T: (1) a linear model; (2) the eight-point interpolation method; and (3) Bloch-McConnell equations (BE) correction algorithm. In the low B1 regime of 0.10 - 0.50 µT, a simple linear model is sufficient to mitigate B1 inhomogeneity of Amide-CEST and NOE effects at 7T.

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