Abstract #1976

3D gagCEST of articular cartilage in the knee at 7 T correlates with clinical findings

Sander Brinkhof¹, Razmara Nizak², Vitaliy Khlebnikov³, Dennis Klomp³, Bennie ten Haken⁴, Jeanine J Prompers³, and Daniel Saris^2,5

¹University Medical Center Utrecht, Utrecht, Netherlands, ²Orthopaedics, University Medical Center Utrecht, Utrecht, ³Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Faculty of Science and Technology, University of Twente, Enschede, Netherlands, ⁵MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Netherlands

The purpose of this study was to assess the sensitivity of 3D gagCEST at 7T in cartilage repair patients with respect to healthy volunteers. Six healthy volunteers were scanned for stability assessments and five patients with cartilage defects were included to assess clinical applicability of the gagCEST sequence. The mean GAG effect size in healthy controls is 10.2 %, which is three times higher than the coefficient of variation in the stability assessments. The results of this study demonstrate the stability of 3D gagCEST at 7T and the results from patients with cartilage defects indicate a correlation with clinical findings.

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