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Abstract #1976

3D gagCEST of articular cartilage in the knee at 7 T correlates with clinical findings

Sander Brinkhof1, Razmara Nizak2, Vitaliy Khlebnikov3, Dennis Klomp3, Bennie ten Haken4, Jeanine J Prompers3, and Daniel Saris2,5

1University Medical Center Utrecht, Utrecht, Netherlands, 2Orthopaedics, University Medical Center Utrecht, Utrecht, 3Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 4Faculty of Science and Technology, University of Twente, Enschede, Netherlands, 5MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Netherlands

The purpose of this study was to assess the sensitivity of 3D gagCEST at 7T in cartilage repair patients with respect to healthy volunteers. Six healthy volunteers were scanned for stability assessments and five patients with cartilage defects were included to assess clinical applicability of the gagCEST sequence. The mean GAG effect size in healthy controls is 10.2 %, which is three times higher than the coefficient of variation in the stability assessments. The results of this study demonstrate the stability of 3D gagCEST at 7T and the results from patients with cartilage defects indicate a correlation with clinical findings.

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