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Abstract #1977

Quantitatively Evaluate the Chemical Exchange Effect in Off-resonance Spin Lock Using Perturbation of Longitudinal Relaxation Rate in Rotating Frame (PLRF) Analysis

Yi Wang1, Yang Fan2, and Jia-Hong Gao1

1Center for MRI Research, Peking University, Beijing, People's Republic of China, 2MR Research Group, GE Healthcare China, Beijing, People's Republic of China

Chemical exchange effect can be evaluated by off-resonance spin-lock sequence (CESL), but it remains unclear whether the effect is accurately reflected. In this study, with the help of perturbation of longitudinal relaxation rate in rotating frame (PLRF) analysis, we quantitatively compared signal from CESL and chemical exchange saturation transfer (CEST) sequences and tested the condition for acquiring high-quality signal from CESL sequence which can accurately reflect chemical exchange effect.

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