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Abstract #1980

Muscular glycogen detection with CEST imaging in living rat at 14.1T

Elise Vinckenbosch1, Hongxia Lei2, Nicolas Kunz1, Masoumeh Dehghani1, and Rolf Gruetter1,2

1Laboratory for functional and metabolic imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM-AIT), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Glycogen is the principle intracellular storage for energetic needs in muscle and information about its spatial distribution would be a great additional tool for traumatology and sport sciences. In this study, we aimed to map in vivo muscular glycogen using CEST imaging in rodent. We have shown that optimal B1 saturation power allowed CEST imaging glycogen distinguishable from the neighboring creatine at 14.1 Tesla. We applied our optimized protocol on muscle after exercise session, resulting in 50% reduction of MTRasym comparing to muscle at resting state. This is supporting the specificity of our method and is consistent with literature.

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