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Abstract #1979

Elegant method to quantify chemical exchange processes for pH CEST imaging

Steffen Goerke1, Johannes Windschuh1, Moritz Zaiss1,2, Jan-Eric Meissner1, Mark E Ladd1, and Peter Bachert1

1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of High-field Magnetic Resonance, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany

A novel concentration-independent approach is presented to determine the pH-dependence of exchange rates employing a single CEST image of a set of model solutions at different pH. Not only the comparatively short acquisition time, but also the robustness against variations in relaxation parameters makes this modality an elegant way to determine exchange rates in vitro. The calibrated functions are required for accurate pH mapping in vivo using CEST, as well as for design of exogenous CEST contrast agents.

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