Meeting Banner
Abstract #1982

The origins of CEST contrast in ischemic tissue: effects of hypotonic stress on the nervous system of Aplysia californica

Tangi Roussel1, Pavel Svehla1, Denis Le Bihan1, and Luisa Ciobanu1

1NeuroSpin, Commisariat à l'Energie Atomique et aux Energies Alternatives, Gif-sur-Yvette, France

Recent CEST MRI methods such as Amide Proton Transfer (APT) imaging allow the detection of brain tumors and stroke by generating novel image contrasts which depend on the chemical exchange. In this paper, we are studying the effects of ischemia on the CEST signal at a tissue level using the nervous system of Aplysia californica, a widespread model in neuroscience. A significant change in the Z spectrum was observed at 2.5 ppm after hypotonic shock in the abdominal ganglion and was quantified as a +2.88% MTR increase. Cell swelling, which is a known phenomenon in ischemic tissue, could potentially cause such effect.

This abstract and the presentation materials are available to members only; a login is required.

Join Here