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Abstract #1983

Simultaneous Acquisition of Multiple Z-spectra using Sinc-Modulated RF Pulse Trains in Gradient Encoded CEST MRI

Hirohiko Imai1, Kiyotaka Miyake2, and Tetsuya Matsuda2

1Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan, 2Department of Systems Science, Graduate School of Informatics, Kyoto University, Kyoto, Japan

We propose a use of sinc-modulated RF pulse train instead of the conventional continuous wave RF irradiation under the presence of constant gradient as a saturation scheme in chemical exchange saturation transfer (CEST) MRI aiming at a simultaneous acquisition of multiple Z-spectra. The proposed method was applied for a glutamic acid solution in water. The multiple Z-spectra could be observed along the gradient encoding direction by repetitive application of the saturation scheme. Thus, the present study shows the potential of the proposed methodology for accelerating the CEST MRI.

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