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Abstract #1984

Investigation of magnitude and phase CEST effects in fixed whole brains and tissue samples: a combined 3T and 9.4T study

Ana-Maria Oros-Peusquens1, Nuno Andre da Silva1, and N. Jon Shah1

1Research Centre Juelich, Juelich, Germany

Saturation transfer effects were investigated in fixed tissue at 3T and 9.4T and a range of saturation powers. Z-spectra on magnitude as well as phase data were studied with high spatial and spectral resolution, also due to the excellent performance of a PCA-based denoising algorithm. The preliminary findings do not support the presence of an APT effect in fixed tissue; however, saturation transfer effects could be enhanced in pathological tissue, similar to in vivo findings in e.g. tumour or stroke. This study opens the way to a systematic investigation of saturation transfer effects in healthy and pathological fixed tissue.

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