Pulsed implementations of RF saturation for MT and ihMT are dependent on the duty cycle of the MT pulse relative to its repetition period. The ihMT signal increases following preparation with high B1, low duty cycle MT pulses. A model was developed to fit ihMT data acquired at different duty cycles, along with the more standard variations in power and offset frequency. Output parameters from the fit were reasonable. The model allowed simulation of the ihMT signal as a function of experimental parameters related to the saturation preparation, and can be used to guide future experiments and/or optimize ihMT.
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