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Abstract #1988

Towards Eliminating Magnetization Transfer (MT) Effect on CEST Quantification Using MR Fingerprinting: Simulations

Pei Han1,2, Zhengwei Zhou3,4, Kui Ying1,2, and Debiao Li3,4,5

1Department of Engineering Physics, Tsinghua University, Beijing, People's Republic of China, 2Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Beijing, People's Republic of China, 3Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, 5Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States

In this work, a new quantitative chemical exchange saturation transfer (q-CEST) method based on MR fingerprinting is developed to eliminate the influence of MT effect. Signal evolutions are generated by using a series of hard saturation pulses with different amplitudes and durations. The dictionary is constructed using the 2-pool model. Simulation experiments based on the 3-pool model were performed, and simulation results show that good mapping accuracy was achieved even in the presence of the MT effect.

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