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Abstract #1989

Towards an Early Detection of Prostate Cancer using Zinc-Sensitive iCEST MRI

Yue Yuan1, Xiaolei Song1, and Jeff Bulte1

1The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States

As compared to normal prostate tissue, prostate cancer cells exhibit a dramatic reduction in zinc content. We have used 19F-based ion-CEST (iCEST) MRI to sense differential Zn2+ levels between normal and malignant prostate cell lines. We were able to observe clear differences in zinc-induced iCEST signal between normal cells and cancer cells, which was validated by microscopy using a zinc-sensitive fluorescent dye. Hence, iCEST MRI may have potential as a new means to non-invasively detect early prostate malignant transformation.

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