Abstract #1990

A biodegradable macromolecular MRI contrast agent for enhanced liver metastasis

Xiaoxuan Zhou¹, Hongjie Hu¹, Yue Qian¹, Yuxin Han², Mingzhou Ye², Jianbin Tang², Peipei Pang³, and Jun Yang³

¹Radiology, Sir Run Run Shaw Hospital, Zhejiang, People's Republic of China, ²Chemical and Biological Engineering, Zhejiang University, Zhejiang, People's Republic of China, ³Life Science, GE healthcare, Shanghai, People's Republic of China

Tumor metastasis accounts for the related mortality, and precise diagnostic imaging of distant metastasis plays a significant role in clinical administration and treatment plan. Enhanced MRI with small-molecule contrast agent (CA) is a favorite imaging modality. However, small-molecule CA has some unsatisfied flaws such as short blood circulation time, low relaxivity and non-specificity. In this study, we synthesized a macromolecular CA with high relaxivity and long blood circulation time, and assessed early liver metastasis with enhanced MRI using this macromolecular CA.

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