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Abstract #1990

A biodegradable macromolecular MRI contrast agent for enhanced liver metastasis

Xiaoxuan Zhou1, Hongjie Hu1, Yue Qian1, Yuxin Han2, Mingzhou Ye2, Jianbin Tang2, Peipei Pang3, and Jun Yang3

1Radiology, Sir Run Run Shaw Hospital, Zhejiang, People's Republic of China, 2Chemical and Biological Engineering, Zhejiang University, Zhejiang, People's Republic of China, 3Life Science, GE healthcare, Shanghai, People's Republic of China

Tumor metastasis accounts for the related mortality, and precise diagnostic imaging of distant metastasis plays a significant role in clinical administration and treatment plan. Enhanced MRI with small-molecule contrast agent (CA) is a favorite imaging modality. However, small-molecule CA has some unsatisfied flaws such as short blood circulation time, low relaxivity and non-specificity. In this study, we synthesized a macromolecular CA with high relaxivity and long blood circulation time, and assessed early liver metastasis with enhanced MRI using this macromolecular CA.

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