Abstract #1997

Feasibility and grading performance of Quantitative Susceptibility Mapping for Hepatic Iron quantification

Huimin Lin¹, Hongjiang Wei², Xu Yan³, Caixia Fu⁴, Stephan Kannengiesse⁵, Chunlei Liu^2,6, and Fuhua Yan¹

¹Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China, ²Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, United States, ³MR Collaboration NE Asia, Siemens Healthcare, Shanghai, People's Republic of China, ⁴Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, People's Republic of China, ⁵MR Applications Predevelopment, Siemens Healthcare, Erlangen, Germany, ⁶The Helen Wills Neuroscience Institute, University of California, Berkeley, CA, United States

This study aimed to evaluate the performance of Quantitative Susceptibility Mapping (QSM) on estimating and grading the liver iron concentration (LIC), using Ferriscan-R2 values as reference. Thirty-three patients suspected of hepatic iron overload were included in this study. The results showed a significant positive correlation between QSM and Ferriscan-based LIC (r=0.924). ROC analysis revealed that QSM could accurately grade LIC for low and moderate iron overload patients, indicating that high-quality QSM maps may allow to reliably estimate and grade iron deposition in the liver.

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