ADC measurement using DWI have shown promise for characterizing focal liver lesions. In this study, we assessed the ability of advanced ADC histogram parameters to distinguish the histological diagnosis and the grade of primary malignant liver cancers. We found that both ADC mean and ADC percentiles could distinguish between tumor types; ADC percentiles were also predictive of tumor grade for HCC and ICC. Advanced ADC histogram analysis may be useful for accurate tumor diagnosis and prediction of tumor grade.
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