Abstract #1999

Simultaneous liver and spleen 2D MRE and 3D MRE acquisitions: Preliminary results

Paul Kennedy ¹, Kevin J. Glaser², Curtis L. Johnson³, Bradley Bolster Jr. ⁴, Jalpan Jani¹, Kashif Khokhar¹, Richard L. Ehman², and Bachir Taouli^1,5

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Mayo Clinic, Rochester, MN, United States, ³Department of Biomedical Engineering, University of Delaware, DE, United States, ⁴Siemens Healthcare, Salt Lake City, UT, United States, ⁵Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

We present initial results of 2D MR elastography (MRE) and 3D MRE acquired in liver and spleen using a dual driver configuration in 13 subjects, 5 healthy and 8 with liver disease. 2D MRE showed a trend to higher stiffness in healthy subjects however in cirrhotic subjects liver stiffness was generally higher with 3D MRE. 3D MRE showed significantly higher liver stiffness in cirrhotic subjects compared to healthy subjects, with spleen stiffness also increased but not reaching significance. Coefficient of variation with single and dual drivers was 5% for liver and spleen in 2D and 3D MRE.

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