Abstract #2006

Inter- and intra-reviewer agreement of region-of-interest-based quantification of liver R2* in patients with iron overload

Camilo A Campo¹, Diego Hernando^1,2, Tilman Schubert¹, Andrew Van Pay¹, and Scott B Reeder^1,2,3,4,5

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

This study evaluated the inter- and intra-reviewer agreement of different region-of-interest (ROI) sampling methods for the quantification of liver R2* (1/T2*) in patients with iron overload. 37 MRI datasets from patients suspected of having liver iron overload were retrospectively analyzed using ROI sampling methods that have been previously reported. Our results demonstrate that the inter- and intra-reviewer agreement of liver R2* quantification improve when using ROIs that are large in size and number. We conclude that researchers and clinicians should strive to sample as much area of the liver by using multiple large ROIs.

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