Liver fibrosis caused by Hepatitis B virus (HBV) is a worldwide health problem. However, liver biopsy as the gold standard of diagnosing and evaluating therapy of liver fibrosis is an invasive examination with possible errors from sampling and intra- and inter-observer interpretation (1, 2). The non-invasive MRI may be a promising modality to evaluate the liver fibrosis. We used diffusion-weighted imaging (DWI) and variable flip angle (VFA) T1 mapping to explore the progression of liver fibrosis caused by HBV infection in a longitudinal study.
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