Intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) for differential diagnosing hepatocellular carcinoma (HCC) from hepatic hemangioma (HHA).

Intravoxel incoherent motion (IVIM) imaging is an extension of diffusion weighted imaging (DWI) that can be used to investigate both diffusion and perfusion changes in tissues. DKI adapts a kurtosis based model to depict the non-Gaussian diffusion process, which could be caused by the presence of different barriers in cellular complex structures (e.g. cell membranes and organelle compartments).Initial application of DKI focused on neuroimaging, Recently, it has also been reported that DKI may help to assess response to treatment in HCC[1]. Comparing the IVIM and DKI parameters between carcinoma (HCC) and hepatic hemangioma(HHA) we found that IVIM and DKI can supply many meritorious parameters, combining with the IVIM and DKI may help in increasing the sensitivity and specificity of antidiastole.