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Abstract #2054

A new technique of SPIO-enhanced MRI: delayed recovery of T2*-weighted signal intensity as a novel diagnostic marker for visualization of irradiated liver parenchyma.

Toshihiro Furuta1,2, Masayuki Yamaguchi1, Manabu Minami3, Osamu Abe2, and Hirofumi Fujii1

1Division of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan, 2Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, 3Department of Radiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

Visualization of irradiated liver parenchyma may assist safety margin assessment in radiotherapy. We demonstrate that an MR imaging technique has the ability to visualize irradiated liver parenchyma after 30-Gy irradiation in a tumor-bearing rat model. In this technique, superparamagnetic iron oxide (SPIO) is administered to label Kupffer cells (KCs) before, rather than after irradiation. A dose of 30-Gy is a lower, more clinically relevant dose than that used in the previous studies. Our results suggest that 30-Gy irradiation delays the recovery of hepatic T2*-weighted signal after SPIO administration. Presumably, irradiation delays degradation process of SPIO in the KCs.

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