Abstract #2054

A new technique of SPIO-enhanced MRI: delayed recovery of T2*-weighted signal intensity as a novel diagnostic marker for visualization of irradiated liver parenchyma.

Toshihiro Furuta^1,2, Masayuki Yamaguchi¹, Manabu Minami³, Osamu Abe², and Hirofumi Fujii¹

¹Division of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan, ²Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, ³Department of Radiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

Visualization of irradiated liver parenchyma may assist safety margin assessment in radiotherapy. We demonstrate that an MR imaging technique has the ability to visualize irradiated liver parenchyma after 30-Gy irradiation in a tumor-bearing rat model. In this technique, superparamagnetic iron oxide (SPIO) is administered to label Kupffer cells (KCs) before, rather than after irradiation. A dose of 30-Gy is a lower, more clinically relevant dose than that used in the previous studies. Our results suggest that 30-Gy irradiation delays the recovery of hepatic T2*-weighted signal after SPIO administration. Presumably, irradiation delays degradation process of SPIO in the KCs.

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