Abstract #2055

Changes in fat distribution and composition during ketogenic diet investigated by MRI and MRS.

Martin Buechert¹, Thomas Lange¹, Peter Deibert², and Paul Urbain³

¹Medical Physics, Department of Radiology, Medical Center – University of Freiburg, Freiburg, Germany, ²Medical Center – University of Freiburg, Freiburg, Germany, ³Department of Medicine I, Section of Clinical Nutrition and Dietetics, Medical Center – University of Freiburg, Freiburg, Germany

Changes in fat distribution and composition during ketonic diet were investigated in a sub group of twelve volunteers of a larger study. Liver fat concentrations in the examined cohort turned out to be surprisingly low compared to patient cohorts with similar BMI measured in other studies. The hypotheses that intra-hepatic fat may be reduced during a ketogenic diet could not be confirmed. However the composition of the sub group may have biased the outcome. While the MRI protocol and analysis worked well, MRS analysis of data acquired with the given protocol in subjects with low hepatic fat reaches its limitations.

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