Lower urinary tract symptoms (LUTS) affect many elderly men and cause urinary obstruction and prostatic enlargement. The aim of this study was to use functional/anatomic MRI for serial imaging of LUTS development in a testosterone/estrogen-supplemented experimental mouse model. These mice exhibited a greater increase in prostate volume and decrease in urethra volume than control mice, and changes in urethral and prostatic volume were strongly inversely correlated. Results suggest that serial MRI could improve understanding of initiation and development of LUTS as well as the origin of clinical symptoms of benign prostatic hyperplasia, and evaluate effects of therapy in mouse models.
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