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Abstract #2086

Magnetic Resonance Imaging Studies of a Testosterone and Estrogen-supplemented Experimental Mouse Model of Lower Urinary Tract Symptoms

Devkumar Mustafi1, Erin McAuley2, Rebecca Valek1, Erica Markiewicz1, Marta Zamora1, Aytekin Oto1, Donald VanderGriend2, and Gregory S Karczmar1

1Radiology, The University of Chicago, Chicago, IL, United States, 2Surgery, The University of Chicago, Chicago, IL, United States

Lower urinary tract symptoms (LUTS) affect many elderly men and cause urinary obstruction and prostatic enlargement. The aim of this study was to use functional/anatomic MRI for serial imaging of LUTS development in a testosterone/estrogen-supplemented experimental mouse model. These mice exhibited a greater increase in prostate volume and decrease in urethra volume than control mice, and changes in urethral and prostatic volume were strongly inversely correlated. Results suggest that serial MRI could improve understanding of initiation and development of LUTS as well as the origin of clinical symptoms of benign prostatic hyperplasia, and evaluate effects of therapy in mouse models.

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